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In the event of an overdose, it is reasonable to employ the usual supportive measure, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy if required.
Sitagliptin is modestly dialysable, approximately 13.5% of dose was removed over a 3- to 4-hour hemodialysis. Prolonged hemodialysis may be considered if clinically appropriate. It is not known if Sitagliptin is dialysable by peritoneal dialysis.
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