Sianem Drug Interactions

In patients treated with Aminoglycosides, the antibacterial activity of Imipenem and Aminoglycosides is additive or synergistic in vitro against some gram positive bacteria, but concomitant administration is generally neither synergistic nor antagonistic in vitro against most strains of Pseudomonas aeruginosa and Enterobacteriaceae. If Aminoglycosides is administered concomitantly with Imipenem and Cilastatin sodium, the drugs may be precipitated so should be administrated in separate containers through the same IV tubing.
In patients treated with Cyclosporine, the CNS side effect of both agents may be increased possibly because of additive or synergistic toxicity.
In patients treated with Gancyclovir, generalized seizures have occurred with co-administration. Do not use concomitantly.
In patients treated with Probenecid, coadministration produces higher and prolonged serum concentrations of Cilastatin but results is only minimal increased in serum concentrations and half-life of Imipenem. Therefore, there is no therapeutic benefit from concomitant use of the drugs. So, concomitant use of Probenecid and the combination is not recommended.