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According to Beers Criteria, Cimetidine should be avoided in older adults with or at high risk of delirium because of potential of inducing or worsening delirium.
Reversible confusional states have been reported and increased risk in severely ill patients, advancing age (i.e. 50 years of age or older), and preexisting liver or renal disease; discontinuation may be warranted.
Cimetidine may increase risk of strongyloidiasis hyperinfection in immunocompromised patient.
Symptomatic response to Cimetidine therapy does not rule out the presence of gastric malignancy.
Injection: Cardiac arrhythmias and hypotension, with rapid administration by IV bolus injection, have been reported rarely.
Use in Children: Cimetidine is not recommended to use in pediatric patient under 16 years of age, unless benefit outweighs risk.
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