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Prolonged use of drug may cause colitis from Clostridium difficile called pseudomembranous colitis which has severity ranging from mild to life-threatening. For mild case, colitis may disappear with drug discontinuation. In severe case, fluid, electrolytes and protein supplement should be administered and patients should be treated with suitable antibiotics.
Use with caution in patients with impaired renal function. Dose adjustment is needed and if prolonged use, monitoring of renal and hepatic function is required.
Prolonged use of broad spectrum antibiotics may result in resistant bacterial and fungal growth.
Administration of high dose cephalosporins with nephrotoxic drugs such as aminoglycosides, or strong diuretics such as furosemide may increase nephrotoxicity, the drug should be used with caution.
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