Sevorane Description

Sevoflurane is a nonflammable liquid anaesthetic agent administered by vaporization. It is a fluorinated derivative of methyl isopropyl ether. Sevoflurane is fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether and has a molecular weight of 200.05.
Sevoflurane has the following physical and chemical properties: Boiling point at 760 mmHg: 58.6°C; specific gravity at 20°C: 1.520-1.525; vapor pressure (calculated) in mmHg^**: 157 mmHg at 20°C, 197 mmHg at 25°C and 317 mmHg at 36°C.
^**Equation for vapor pressure (calculated), mmHg: Log₁₀P_vap=A+B/T, where: A=8.086, B=-1726.68 and T=°C+273.16°K.
Distribution Partition Coefficients at 37°C: Blood/gas: 0.63-0.69; water/gas: 0.36; olive oil/gas: 47.2-53.9; brain/gas: 1.15.
Mean Component/Gas Partition Coefficients at 25°C for Polymers Used Commonly in Medical Applications: Conductive rubber: 14; butyl rubber: 7.7; polyvinyl chloride: 17.4; polyethylene: 1.3.
Sevoflurane is nonflammable and non-explosive as defined by the requirements of International Electrotechnical Commission 601-2-13. It is a clear, colorless liquid containing no additives or chemical stabilizers. It is nonpungent. It is miscible with ethanol, ether, chloroform and petroleum benzene and is slightly soluble in water.
Sevoflurane is stable when stored under normal room lighting conditions. No discernible degradation of sevoflurane occurs in the presence of strong acids or heat. The only known degradation reaction is through direct contact with CO₂ absorbents (soda lime and Baralyme), producing pentafluoroisopropenyl fluoromethyl ether (PIFE, C₄H₂F₆O), a haloalkene derivative, also known as compound A, and trace amounts of pentafluoromethoxy isopropyl fluoromethyl ether (PMFE, C₅H₆F₆O), also known as Compound B, in the clinical setting. Sevoflurane is not corrosive to stainless steel, brass, aluminum, nickel-plated brass, chrome-plated brass or copper beryllium alloy.