Selrotine Overdosage

Symptoms: Alopecia, decreased libido, diarrhea, ejaculation disorder, fatigue, insomnia, serotonin syndrome, and somnolence. The most common signs and symptoms associated with nonfatal Sertraline overdosage were agitation, dizziness, nausea, somnolence, tachycardia, tremor and vomiting.
Other important adverse events reported with Sertraline overdose (single or multiple drugs) include bradycardia, bundle branch block, coma, convulsion, delirium, hallucinations, hypertension, hypotension, manic reactions, pancreatitis, QT interval prolongation, serotonin syndrome, stupor and syncope.
Treatment: There are no specific antidote. Establish and maintain an airway; ensure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage.
Monitor cardiac and vital signs along with general symptomatic and supportive measures. SSRIs-induced seizures that fail to respond spontaneously may respond to diazepam.
Because of the large volume of distribution of SSRIs, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit.