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Overdose: Overdosage of NSAIDs can cause lethargy, drowsiness, nausea, vomiting and epigastric pain; these manifestations generally are reversible with supportive care. GI bleeding also has been reported. Rarely, hypertension, acute renal failure, respiratory depression and coma may occur. Anaphylactoid reactions have been reported with therapeutic use of NSAIDs and may occur following an overdosage.
Treatment: Treatment of NSAIDs overdosage involves symptomatic and supportive care; there is no specific antidote for NSAIDs overdosage. During the first 4 hours after overdosage, emesis and/or administration of activated charcoal (60-100 g in adults) and/or osmotic cathartic may be useful in symptomatic patients or in those who reportedly ingested a large overdosage.
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