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Hypervolemic or euvolemic hyponatremia: Treatment of clinically significant hypervolemic or euvolemic hyponatremia (serum sodium <125 mEq/L or less marked hyponatremia that is symptomatic and resistant to fluid restriction), including patients with heart failure and syndrome of inappropriate antidiuretic hormone (SIADH).
Important limitations: Not indicated for use when urgent treatment of hyponatremia is required to prevent or treat serious neurological symptoms. It has not been established that raising serum sodium with Tolvaptan provides symptomatic benefit.
Adjunct treatment of volume overload in heart failure: Volume overload in heart failure when adequate response is not obtained with other diuretics (e.g., loop diuretics).
Important limitations: Tolvaptan should be used in combination with other diuretics, such as loop diuretics, thiazides, and aldosterone antagonists).
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