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There are no data available from clinical trials on overdose with Salflumix Easyhaler, however data on overdose with both drugs are given as follows: The signs and symptoms of salmeterol overdose are dizziness, increases in systolic blood pressure, tremor, headache and tachycardia. If Salflumix Easyhaler therapy has to be withdrawn due to overdose of the β-agonist component of the drug, provision of appropriate replacement steroid therapy should be considered. Additionally, hypokalaemia can occur and therefore serum potassium levels should be monitored. Potassium replacement should be considered.
Acute: Acute inhalation of fluticasone propionate doses in excess of those recommended may lead to temporary suppression of adrenal function. This does not need emergency action as adrenal function is recovered in a few days, as verified by plasma cortisol measurements.
Chronic overdose of inhaled fluticasone propionate: Adrenal reserve should be monitored and treatment with a systemic corticosteroid may be necessary. When stabilised, treatment should be continued with an inhaled corticosteroid at the recommended dose. Refer to Systemic corticosteroid effects under Precautions.
In cases of both acute and chronic fluticasone propionate overdose Salflumix Easyhaler therapy should be continued at a suitable dosage for symptom control.
