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Musculoskeletal effects: Myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported in patients receiving statins, including rosuvastatin.
Rosuvastatin should be used with caution in patients with predisposing factors for myopathy (e.g. advanced age [65 years or older], renal impairment, inadequately treated hypothyroidism).
Hepatic effects: Rosuvastatin should be used with caution in patients with a history of liver disease (e.g., chronic alcoholic liver disease) and/or in patients who consume substantial amounts of alcohol.
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