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Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of parent antibiotic lincomycin. Clindamycin is active in vitro against Propionibacterium acnes causing acne vulgaris.
In comparison with oral tetracycline, Clindamycin 1% Topical Solution reduced acne lesions by 60% compared to 49% for tetracycline. In additional controlled studies, Clindamycin 1% Topical Solution caused a 58% reduction in acne lesions compared to a 33% reduction with placebo (alcoholic vehicle).
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