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Adult: Usual dosage: 20 mg/day.
Initial dosage: 5 mg once daily.
Dosage titration: Increase in 5 mg increments to 10 mg/day (5 mg twice a day), 15 mg/day (5 and 10 mg as separate doses), and 20 mg/day (10 mg twice a day). The minimum recommended interval between dose increases is 1 week.
Renal function impairment: Severe renal impairment (creatinine clearance [CrCl] 5 to 29 mL/min): Usual dose: A target dosage of 5 mg twice daily is recommended.
Mode of Administration: Memantine hydrochloride is administered orally without regard to meals.
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