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This product is highly specific for fibrinogen, but overdose may still result in a reduction in fibrinogen and other coagulation factors. In the event of overdose there may be an increased risk of bleeding. In most cases, physiological regeneration is sufficient to replenish these factors after discontinuation of treatment with Recomlyse. In case of severe prolonged bleeding, substitution therapy may be considered (plasma, fresh whole blood, platelets) and synthetic antifibrinolytic agents can be used if necessary.