Schizophrenia 50 mg bid (day 1), may be increased to 25-50 mg in 2-3 divided doses on day 2 & 3, w/ target dose of 300-400 mg by day 4.
Manic episodes w/ bipolar disorder 50 mg (day 1), may be increased to 100 mg on day 2, day 3, & 400 mg (day 4). May be adjusted w/in 400-800 mg/day, & no incremental >200 mg/day.
Depressive episodes associated w/ bipolar disorder 50 mg (day 1) once daily at bedtime. 100 mg (day 2) & increase 100 mg until 300 mg (day 4). Normal range: 300 mg once daily.
Maintenance treatment in bipolar I disorder in combination w/ lithium or divalproex Normal range: 400-800 mg/day. Max: 800 mg/day
Elderly Initially 50 mg/day, may increase to 50 mg/day until target.
Hepatic impairment Initially 25 mg/day & may increase 25-50 mg until target.