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Patients who have previously exhibited hypersensitivity to it.
Because the potential exists for cross-sensitivity to aspirin or other nonsteroidal anti-inflammatory drugs, mefenamic acid should not be given to patients in whom these drugs induce symptoms of bronchospasm, allergic rhinitis or urticaria.
Mefenamic acid is contraindicated in patients with upper or lower gastrointestinal ulceration or chronic inflammation. Mefenamic acid should be avoided in patients with preexisting renal disease.
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