Pilanz Overdosage

The most common of Olanzapine overdosage symptoms (>10% incidence) include agitation and/or aggressiveness, dysarthria, tachycardia, miosis, various extrapyramidal symptoms, hypersalivation and reduce level of consciousness ranging in severity from sedation to coma.
Less commonly reported of Olanzapine overdosage symptoms but potentially medically serious events included aspiration, cardiopulmonary arrest, cardiac arrhythmias, delirium, possible neuroleptic malignant syndrome, respiratory depression and/or arrest, convulsions, hypertension or hypotension and coma.
There is no specific antidote for Olanzapine. Standard treatment of overdose may be indicated (i.e. gastric lavage, administration of activated charcoal). Symptomatic treatment and monitoring of vital organ function should be instituted according to clinical presentation, including treatment of hypotension and circulatory collapse and support of respiratory function. Continuous cardiovascular and respiratory monitoring are necessary.