Pemetrexed Eurodrug Use In Pregnancy & Lactation

Women of childbearing potential/Contraception in males and females: Pemetrexed can have genetically damaging effects. Woman of childbearing potential must be use effective contraception during treatment with pemetrexed and for 6 months following completion of treatment.
Sexually mature males are advised to use effective contraceptive measures and not to father a child during the treatment and up to 3 months thereafter.
Pregnancy: There are no data from the use of pemetrexed in pregnant women but pemetrexed, like other anti-metabolites, is suspected to cause serious birth defects when administered during pregnancy. Animal studies have shown reproductive toxicity (see Pharmacology: Toxicology: Preclinical safety data under Actions). Pemetrexed should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus (see Precautions).
Breast-feeding: It is unknown whether pemetrexed is excreted in human milk and adverse reactions on the breast-feeding child cannot be excluded. Breast-feeding must be discontinued during pemetrexed therapy (see Contraindications).
Fertility: Owing to the possibility of pemetrexed treatment causing irreversible infertility, men are advised to seek counselling on sperm storage before starting treatment.