Paracetamol Kabi Drug Interactions

Probenecid causes an almost 2-fold reduction in clearance of paracetamol by inhibiting its conjugation with glucuronic acid. A reduction in the paracetamol dose should be considered if it is to be used concomitantly with probenecid.
Salicylamide may prolong the elimination half-life of paracetamol.
The metabolism of paracetamol is impaired in patients taking enzyme-inducing medicinal products such as rifampicin, barbiturates, tricyclic antidepressants, isoniazid and some antiepileptics (carbamazepine, phenytoin, phenobarbital, primidone).
Isolated reports describe unexpected hepatotoxicity in patients taking alcohol or enzyme-inducing medicinal products (see Overdosage).
Concurrent administration of paracetamol and chloramphenicol may prolong the action of chloramphenicol.
Concurrent administration of paracetamol and AZT (zidovudine) enhances the tendency to neutropenia.
Concurrent administration of paracetamol and oral contraceptives may reduce the elimination half-life of paracetamol.
Concomitant use of paracetamol (4 g per day for at least 4 days) with oral anticoagulants may lead to slight variations of INR values. In this case, increased monitoring of INR values should be conducted during the period of concomitant use as well as for 1 week after paracetamol treatment has been discontinued.
Caution should be taken when paracetamol is used concomitantly with flucloxacillin as concurrent intake has been associated with high anion gap metabolic acidosis due to pyroglutamic acidosis, especially in patients with risk factors (see Precautions).