Caution should be exercised in patients with known hypersensitivity to drugs. The general precautions for intra-articular injections should be observed. OSTENIL should be injected accurately into the joint cavity. Avoid injections into blood vessels or surrounding tissues. As no clinical evidence is available on the use of hyaluronic acid in children, pregnant and lactating women or in inflammatory joint diseases such as rheumatoid arthritis or Bechterew disease, treatment with OSTENIL is not recommended in these cases. Do not use if the pre-filled syringe or sterile pack are damaged. Store below 30°C.