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There are no known significant interaction.
Entecavir is primarily eliminated by the kidneys, co-administration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the co-administered drug. Co-administration of entecavir with lamivudine, adefovir dipivoxil, or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of co-administration with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when entecavir co-administered with such drugs.
Food delays absorption and reduces AUC by 18%-20%.
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