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Since carboxymethylcellulose sodium is pharmacologically inert and not absorbed systemically, systemic intoxication from topical overdose is not expected from ocular administration of OPTIVE/OPTIVE UD. Additionally, no adverse effects are expected should accidental systemic overdose occur.
Glycerin is a small molecule that is found throughout the body as a natural metabolic compound. In the low concentrations present in OPTIVE/OPTIVE UD, it will combine with endogenous glycerin in the body tissues without significant effect. Systemic intoxication from topical overdose is not expected given the low systemic exposure of glycerin via topical administration of OPTIVE/OPTIVE UD.
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