Olimel N12E Mechanism of Action

Pharmacotherapeutic group: Solutions for parenteral nutrition/combinations. ATC code: B05BA10.
Pharmacology: Pharmacodynamics: OLIMEL's content in nitrogen (L series amino acids) and energy (glucose and triglycerides) enables maintaining an adequate nitrogen/energy balance.
This formulation also contains electrolytes.
The lipid emulsion included in OLIMEL N12E is an association of refined olive oil and refined soya-bean oil (ratio 80/20), with the following approximate distribution of fatty acids: 15% saturated fatty acids (SFA), 65% monounsaturated fatty acids (MUFA), 20% polyunsaturated essential fatty acids (PUFA).
The phospholipid/triglyceride ratio is 0.06.
Olive oil contains significant amounts of alpha-tocopherol which, combined with a moderate PUFA intake, contribute to improved vitamin E status and the reduction of lipid peroxidation.
The amino acid solution contains 17 L-series amino acids (including 8 essential amino acids), which are required for protein synthesis.
Amino acids also represent an energy source. Their oxidation results in excretion of nitrogen in the form of urea.
The amino acid profile is as follows: Essential amino acids/total amino acids: 44.8%.
Essential amino acids (g)/total nitrogen (g): 2.8%.
Branched-chain amino acids/total amino acids: 18.3%.
The carbohydrate source is glucose.
Pharmacokinetics: The ingredients of OLIMEL N12E (amino acids, electrolytes, glucose and lipids) are distributed, metabolised and removed in the same way as if they had been administered individually.
Toxicology: Preclinical safety data: No preclinical studies with OLIMEL N12E have been performed.
Preclinical toxicity studies performed using the lipid emulsion contained in OLIMEL N12E have identified the changes, which are conventionally found with a high intake of a lipid emulsion: fatty liver, thrombocytopenia and elevated cholesterol.
Preclinical studies performed using the solutions of amino acids and glucose contained in OLIMEL N12E of different qualitative compositions and concentrations have not, however, revealed any specific toxicity.