Class III or IV heart failure within the last 6 months.
Cardiac arrhythmias requiring anti-arrhythmic treatment with Class Ia or Class III antiarrhythmic drugs.
Decompensated heart failure requiring hospitalization within the last 6 months.
Hypersensitivity reaction to Fingolimod or any of the excipients.
Mobitz type II second-degree or third-degree atrioventricular block (history or current), unless the patient has a functional pacemaker.
Myocardial infarction within the last 6 months.
QTc interval at baseline 500 milliseconds or greater.
Sick-sinus syndrome (history or current), unless the patient has a functional pacemaker.
Stroke within the last 6 months.
Transient ischemic attack within the last 6 months.
Unstable angina within the last 6 months.
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