Noveron Dosage/Direction for Use

Recommended dose: Doses of neuromuscular blockers need to be carefully titrated for individual patients according to response, and may vary with the procedure, the other drug administered, and the state of the patient. Monitoring of the degree of block is recommended in order to reduce the risk.
Neuromuscular blockade (intermediate duration) during surgery and intubation initially by intravenous injection: Adult: Initially 0.6 mg/kg; (by intravenous injection) maintenance 0.15 mg/kg, alternatively (by intravenous infusion) maintenance 0.3-0.6 mg/kg/hr, adjusted according to response.
**Higher dose of 1 mg/kg are recommended for intubation during rapid sequence induction for anesthesia.
Elderly: Initially 0.6 mg/kg; (by intravenous injection) maintenance 0.075-0.1 mg/kg, alternatively (by intravenous infusion) maintenance up to 0.4 mg/kg/hr, adjusted according to response.
Neonate and child: Same as adult dose.
Neuromuscular blockade (intermediate duration) during intensive care Initially by intravenous injection: Adult: Initially 0.6 mg/kg, initial dose is optional; (by intravenous infusion) maintenance 0.3-0.6 mg/kg/hr for first hour, then (by intravenous infusion), adjusted according to response.
Administration in hepatic and renal impairment: The recommended initial dose is 0.6 mg/kg by intravenous injection and a reduced maintenance dose of 0.075-0.1 mg/kg by intravenous injection, or 0.3-0.4 mg/kg/hr by continuous infusion.
Doses at extreme of bodyweight: To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal bodyweight.
Rocuronium bromide may exhibit a prolonged duration and a prolonged spontaneous recovery in obese patients, when the administered doses are calculated on actual bodyweight.
Mode of administration: Rocuronium bromide solution for injection is administered intravenously (i.v.) either as a bolus injection or as a continuous infusion.
Noveron could be diluted in infusion solutions: 0.9% sodium chloride, 5% dextrose, 5% dextrose in 0.9% sodium chloride, ringer's lactate solution and water for injection use within 72 hours of preparation (see Storage condition under Storage).