NIKP-Montelukast Dosage/Direction for Use

For mild persistent asthmatic, Montelukast chewable tablet 5 mg should be taken once daily. For moderate to severe asthma, Montelukast chewable tablet 5 mg should be taken once daily concomitantly with inhaled corticosteroids to provide additional benefit. The dose should be taken in the evening and should be chewed thoroughly before swallowing.
For allergic rhinitis, Montelukast chewable tablet 5 mg should be taken once daily in the evening and should be chewed thoroughly before swallowing. In patients who are not adequately controlled on the standard therapy according to specialized physicians' consideration, concomitant administration of Montelukast chewable tablet 5 mg may result in further improvement of symptoms. The time of administration may be individualized to suit patient needs.
General Recommendations: The therapeutic effect of Montelukast on parameters of asthma control occurs within one day. Patients should be advised to continue taking Montelukast while their asthma is controlled, as well as during periods of worsening asthma.
No dosage adjustment is necessary for pediatric patients, for the elderly, for patients with renal insufficiency, or mild-to-moderate hepatic impairment, or for patients of either gender.
Therapy with Montelukast in Relation to Other Treatments for Asthma: Montelukast can be added to a patient's existing treatment regimen.
Reduction in Concomitant Therapy: Bronchodilator Treatments: Montelukast can be added to the treatment regimen of patients who are not adequately controlled on bronchodilator alone. When a clinical response is evident (usually after the first dose), the patient's bronchodilator therapy can be reduced as tolerated.
Inhaled Corticosteroids: Treatment with Montelukast provides additional clinical benefit to patients treated with inhaled corticosteroids. A reduction in the corticosteroid dose can be made as tolerated. The dose should be reduced gradually with medical supervision. In some patients, the dose of inhaled corticosteroids can be tapered off completely. Montelukast should not be abruptly substituted for inhaled corticosteroids.