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Pharmacology: Mesacol is designed to disintegrate and dissolve in the terminal portion of ileum. Thus, large amount of 5-aminosalicylic acid is made available at the desired site of action ie, distal ileum and large intestine, with minimal GI upset or systemic absorption. Very small amount of 5-aminosalicylic acid is absorbed from the large intestine. High levels of the drug continue to remain in the large intestine to exert its anti-inflammatory effect.
Teratogenicity: At doses 5-20 times the human dose (100-400 mg/kg in rats), reduced fetal weight, retarded ossifications and immaturity of fetal visceral organs has been noted in rats.
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