Memotin Overdosage

Symptoms: Signs and symptoms associated with memantine overdosage in clinical trials and from worldwide marketing experience alone or in combination with other drugs and/or alcohol include agitation, asthenia, bradycardia, coma, confusion, dizziness, electrocardiogram (ECG) changes, increased blood pressure, lethargy, loss of consciousness, psychosis, restlessness, slowed movement, somnolence, stupor, unsteady gate, visual hallucinations, vertigo, vomiting, and weakness. The largest known ingestion of memantine worldwide was 2 g in a patient who took memantine in conjunction with unspecified antidiabetic medications. The patient experienced agitation, coma, and diplopia but subsequently recovered.
One patient participating in a memantine ER clinical trial unintentionally took memantine ER 112 mg daily for 31 days and experienced an elevated serum uric acid, elevated serum alkaline phosphatase, and low platelet count.
Treatment: Utilize general supportive measures and symptomatic treatment. Elimination of memantine can be enhanced by acidification of urine.