Melox Special Precautions

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. Use the drug with caution in patients with cardiovascular disease or risk factors for cardiovascular disease.
NSAIDs can lead to onset of new hypertension or worsening existing hypertension, therefore increase the incidence of cardiovascular events. Use the drug with caution and closely monitor blood pressure during the initiation of NSAIDs treatment and throughout the course.
Long-term use of NSAIDs can result in renal papillary necrosis and renal medullary changes; as the prostaglandin formation and renal blood flow are reduced. Patients at risk are those with impaired renal function, heart failure, liver dysfunction, the elderly, those taking diuretics, ACE inhibitors, and angiotensin II antagonists.
Monitoring for signs or symptoms of gastrointestinal tract hemorrhage and anemia is suggested. For long-term treatment, patients should have complete blood count test (CBC) and chemistry profile check, including hemoglobin or hematocrit.
Discontinue the drug in case of signals and symptoms associated with the development of hepatic or renal disease, systemic manifestations, persistent or worsening of abnormal liver test.
Use in Children: Safety and efficacy of Meloxicam has not been established in children younger than 2 years old.
Use in the Elderly: Increased concentration may occur in elderly patient (particularly in females) because they are at higher risk for serious gastrointestinal ulcer. However, no specific dosage adjustment is recommended.