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Pharmacology: Mechanism of Action: Calcitriol is one or the most important active metabolites of vitamin D3. It is normally formed in the kidneys from its precursor, 25-hydroxycholecalciferol (25-HCC).
Calcitriol promotes intestinal absorption of calcium and regulates bone mineralization. The plasma half-life of calcitriol lasts about 3-5 days. The key role of calcitriol in the regulation of calcium homeostasis which includes stimulating effects on osteoblastic activity in the skeleton provides a sound pharmacological basis for its therapeutic effects in osteoporosis.
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