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Alfacalcidol or 1-α-hydroxyvitamin D3 is one of vitamin D analogue. Alfacalcidol is rapidly converted in liver to 1,25-dihydroxyvitamin D3 {1,25-(OH)2D3}, the metabolite of vitamin D3 which acts as a regulator of calcium and phosphate metabolism.
Impaired endogenous production of 1,25-dihydroxyvitamin D3 by the kidneys appears to contribute to the disturbances in mineral metabolism found in several disorders, including renal bone disease, hypoparathyroidism and vitamin D-dependent rickets. These disorders require high doses of vitamin D for their correction.
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