Mupirocin is usually well tolerated but local reactions such as burning, stinging, and itching may occur after the application of mupirocin to the skin.
Burning, stinging, or pain (1.5%); itching (1%); rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increase exudate (less than 1 %); systemic reaction (rare).