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In adults, drowsiness, tachycardia, and headache have been reported after overdoses (40-180 mg) of Loratadine tablets.
In children, extrapyramidal manifestations and palpitations have been reported with overdoses (exceeding 10 mg) of Loratadine syrup.
Treatment involves symptomatic and supportive care. In acute overdosage, the stomach should be emptied immediately by inducing emesis with ipecac syrup. Activated charcoal administered after emesis maybe useful in preventing absorption of Loratadine. Gastric lavage with a 0.9% sodium chloride solution may be performed, if induction of vomiting is unsuccessful or contraindicated.
Loratadine is not removed by hemodialysis, and not known whether it is removed by peritoneal dialysis.
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