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Initially 300 mg (1 capsule) daily which may be gradually increased to 900 mg (3 capsules) in divided doses.
In manic depressive disease up to 1.8 gm (6 capsules) daily may be given.
The dosage must be adjusted to maintain plasma levels in the therapeutic ranges, which is between 0.5 and 1.5 mEq/L and careful observation is necessary for toxic effects.
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