Lipz/Lipz ED Drug Interactions

Decreased effect: The levels/effects of LIPZ and LIPZ ED may be decreased by: antibiotics (griseofulvin, penicillins, or tetracyclines), aprepitant, barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, HCV protease inhibitors, HIV protease inhibitors, hydantoins, modafinil, NNRTIs (e.g., efavirenz), oxcarbazepine, phenytoin, rifamycins, rufinamide, St. John's wort, topiramate, and thiazolidinediones.
LIPZ and LIPZ ED may decrease the levels/effects of: lamotrigine and valproic acid.
Increased effect: The levels/effects of LIPZ and LIPZ ED may be increased by: atorvastatin, tranexamic acid (The risk of hormonal contraceptive related thrombotic events may be increased).
LIPZ and LIPZ ED may increase the levels/effects of: tricyclic antidepressants, beta blockers, caffeine, corticosteroids, theophyllines, cyclosporine, and selegiline.
Other effects: Fluconazole: The therapeutic efficacy of oral contraceptives may be decreased while the blood levels of ethinyl estradiol is increased. Consider an alternate form of birth control.
Anticoagulants: Because hormonal contraceptives can increase levels of certain circulating clotting factors and reduce antithrombin III levels, therapeutic efficacy of the anticoagulants may be decreased by hormonal contraceptives. However, both an increased and decreased effect has occurred.
Benzodiazepines: Hormonal contraceptives may increase the clearance of benzodiazepines that undergo glucuronidation (e.g., lorazepam, oxazepam, temazepam) because of increased metabolism. Combination hormonal contraceptives with alprazolam, chlordiazepoxide, diazepam, and triazolam may inhibit hepatic mixed function oxidases leading to a decrease in benzodiazepine oxidation rate (may prolong the half-life of benzodiazepines).