Lipo-Dox Caution For Usage

Instructions for use/handling: Do not use material if precipitation or any other particulate matter are present. Caution should be exercised in handling pegylated liposomal doxorubicin. The use of gloves is required. If pegylated liposomal doxorubicin comes into contact with skin or mucosa, immediately wash thoroughly with soap and water. Pegylated liposomal doxorubicin should be handled and disposed of in a manner consistent with that of other anticancer drugs.
Determine the dose of pegylated liposomal doxorubicin to be administered based on the recommended dose and the patient's body surface area. Take the appropriate volume of pegylated liposomal doxorubicin up into a sterile syringe. Aseptic technique must be strictly observed since no preservation or bacteriostatic agent is present in pegylated liposomal doxorubicin HCl.
The appropriate dose of pegylated liposomal doxorubicin must be diluted in Dextrose 5% in Water prior to administration. For doses <90 mg, dilute in 250 ml of Dextrose 5% in Water, and for doses ≥90 mg, dilute in 500 ml of Dextrose 5% in Water.
Do not use other diluents or solution containing any bacteriostatic agent, such as benzyl alcohol, which will cause precipitation.
It is recommended that the pegylated liposomal doxorubicin infusion line be connected through the side port of an intravenous infusion of Dextrose 5% in Water. The infusion may be given through a peripheral vein. Do not use with in-line filters.
Incompatibilities: Do not mix with other drugs.