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No interaction studies have been performed with levocetirizine (including no studies with CYP3A4 inducers).
Studies with the racemate compound cetirizine demonstrated that there were no clinically relevant adverse interactions (with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide and diazepam).
Concomitant administration of cetirizine and ritonavir may increase the AUC and half-life and decreased the clearance of cetirizine; the disposition of ritonavir was not altered.
Concomitant use of cetirizine and theophylline resulted in decrease clearance (16%) of cetirizine; the disposition of theophylline was not altered.
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