Leqembi Caution For Usage

Incompatibilities: Not applicable.
Special precautions for disposal and other handling: Parenteral medicinal products should be inspected visually for particulate matter and discolouration prior to administration. In the event of either being observed, discard the medicinal product.
Preparation of infusion solution: Calculate the dose, the total volume of lecanemab solution required, and the number of vials needed based on the patient's actual body weight. Each vial contains a lecanemab concentration of 100 mg/mL.
Withdraw the required volume of lecanemab from the vial(s) and add to 250 mL 0.9% sodium chloride solution for injection.
Gently invert the infusion bag containing the lecanemab diluted solution to mix completely. Do not shake.
Infusion bags manufactured using polypropylene, polyvinyl chloride, co-extruded polyolefin/polyamide, or ethylene/propylene copolymer have been confirmed to be compatible for administration of lecanemab.
After dilution, immediate use is recommended.
Administration of infusion solution: Prior to infusion, allow the lecanemab diluted solution to warm to room temperature.
Infuse the entire volume of lecanemab intravenously over approximately 1 hour through an intravenous line containing a terminal low-protein binding 0.2 micron in-line filter (compatible filter materials include polytetrafluoroethylene, polyethersulfone, polycarbonate, polyvinylidenedifluoride, polypropylene, polyurethane and polysulfone). Flush infusion line to ensure all lecanemab is administered.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.