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Pharmacology: Pharmacodynamics: Levofloxacin is a Fluoroquinolone anti-infective agent which experts a broad spectrum potent anti-bacterial activity against organisms causing ophthalmological infections, including gram-positive bacteria, gram negative bacteria and anaerobic bacteria. Levofloxacin inhibits DNA synthesis in susceptible organisms via inhibition of type II topoisomerase (DNA gyrase) and topoisomerase IV.
Susceptible strains: Levofloxacin has been shown to be active against gram-positive and gram-negative bacteria such as: Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus sp., Streptococcus group G, Streptococcus pneumoniae, α-hemolytic streptococci (viridans group), and Corynebacterium spp.
Gram-negative bacteria: Serratia marcescens, Haemophilus influenzae or parainfluenzae, Pseudomonas aeruginosa, Acinetobacter lwoffii, Moraxella sp., Klebsiella sp., Enterobacter sp., and Proteus sp.
Pharmacokinetics: After ocular instillation, Levofloxacin is well maintained in the tear-film.
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