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Recommended Doses: Hypertension: Children 6-16 years: 0.7 mg/kg once daily (maximum: 50 mg/day); adjust dose based on response; doses >1.4 mg/kg (maximum: 100 mg) have not been studied.
Adults: Usual starting dose: 50 mg once daily; can be administered once or twice daily with total daily doses ranging from 25-100 mg.
Patients receiving diuretics or with intravascular volume depletion: Usual initial dose: 25 mg.
Nephropathy in patients with type 2 diabetes and hypertension: Adults: Initial: 50 mg once daily; can be increased to 100 mg once daily based on blood pressure response.
Stroke reduction (HTN with LVH): Adults: 50 mg once daily (maximum daily dose: 100 mg); may be used in combination with a thiazide diuretic.
Dosing adjustment in renal impairment: Children: Use is not recommended if GFR<30 mL/minute/1.73 m2.
Adults: No adjustment necessary.
Dosing adjustment in hepatic impairment: Children: No specific dosing recommendations, however it may be advisable to initiate therapy at a reduced dosage.
Adults: Reduce the initial dose to 25 mg/day; divide dosage intervals into two.
Mode of Administration: May be administered with or without food.
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