Kidmin Mechanism of Action

Pharmacology: KIDMIN administered by TPN, exerted the following nutritional effects in animals such as chronic renal failure animals (7/8 nephrectomy rats and 7/8 renal artery-ligated dogs) and acute renal failure animals (mercuric chloride-induced renal failure rats and total nephrectomy rats): Favorable body weight gain and nitrogen balance.
Normalized aminogram in blood and BCAA levels in muscle.
Increased uptake of N-leucine into blood protein fraction.
Smaller increase in blood urea nitrogen.
The amino acid-providing effect of KIDMIN was studied in 7/8 nephrectomized rats on a low-protein diet and the following nutritional effects were observed.
Improvement in nutritional status as evidenced by body weight gain, nitrogen balances and normalized blood aminogram.
No increase in blood urea nitrogen.
CLINICAL STUDIES: Clinical trials were conducted in 218 patients with acute or chronic renal failure, mainly those who needed blood purification treatment and the following results were obtained.
In the total parenteral nutrition (central vein infusion) in patients in whom oral nutrition was not tolerated, KIDMIN showed favorable effect on serum total protein, albumin and rapid-turnover protein with smaller changes in serum aminograms and alleviated an increase in blood urea nitrogen.
In the peripheral use of KIDMIN as a supplement to the oral intake of protein, the nutritional parameters such as serum total protein, transferrin and Val/Gly ratio were favorably maintained.
Pharmacokinetics: When ¹⁴C-labeled KIDMIN was infused to normal 12 week-old rats and to 7/8 nephrectomized rats by TPN, the radioactivity was rapidly distributed throughout the body, with 50 - 90% incorporation to the protein fractions of the plasma, muscle and major organs such as liver, kidney and spleen from 3 to 72 hours after infusion. The expiratory excretion relative to the administered radioactivity was 32% in normal rats and 34% in nephrectomized rats up to 72 hours after infusion and the urinary excretion relative to the administered radioactivity was 4.6% and 4.9%, respectively.