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Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels.
Drugs that form hardly soluble compounds with calcium (e.g. tetracyclines, quinolines such as ciprofloxacin and norfloxacin as well as drugs containing iron, fluoride or estramustine) should not be taken at the same time with Ketosteril to avoid disturbed absorption of the active substances. An interval of at least two hours should elapse between the ingestion of Ketosteril and these drugs.
The susceptibility to cardioactive glycosides and hence the risk for arrhythmia will increase if Ketosteril produces elevated serum calcium levels (see Adverse Reactions).
Uraemic symptoms improve under therapy with Ketosteril. Thus, in case of aluminium hydroxide administration, the dose of this drug has to be reduced if necessary. Serum phosphate levels should be monitored for a decrease.
