Ketesse Contraindications

KETESSE must not be administered in the following cases: patients hypersensitive/with hypersensitivity to the active substance, to any other NSAIDs, or to any of the excipients of the product.
Patients in whom substances with a similar action (e.g. acetylsalicylic acid, or other NSAIDs) precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic oedema.
Known photoallergic or phototoxic reactions during treatment with ketoprofen or fibrates.
Patients with history of gastrointestinal bleeding or perforation, related to previous NSAID therapy.
Patients with active peptic ulcer/gastrointestinal haemorrhage or any history of gastrointestinal bleeding, ulceration or perforation.
Patients with chronic dyspepsia.
Patients who have other active bleeding or bleeding disorders.
Patients with Crohn's disease or ulcerative colitis.
Patients with severe heart failure; patients with moderate to severe renal impairment (creatinine clearance ≤59 ml/min).
Patients with severely impaired hepatic function (Child-Pugh score 10-15).
Patients with haemorrhagic diathesis and other coagulation disorders.
Patients with severe dehydration (caused by vomiting, diarrhoea or insufficient fluid intake).
During the third trimester of pregnancy and lactation period (see Use in Pregnancy & Lactation).
Solution for injection: KETESSE Solution for injection/infusion is contraindicated for neuraxial (intrathecal or epidural) administration due to its ethanol content.