Hypersensitivity to the active substance or to any of the excipients listed in Description or to benzazepine or benzazepine derivatives (see Precautions); Elevated liver enzymes and/or signs or symptoms of liver injury prior to initiation of treatment that meet the requirements for permanent discontinuation of tolvaptan (see Precautions); Anuria; Volume depletion; Hypernatraemia; Patients who cannot perceive or respond to thirst; Pregnancy (see Use in Pregnancy & Lactation); Breast-feeding (see Use in Pregnancy & Lactation).