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Itopride is metabolized by the flavine monooxygenase not by the CYP450, therefore the drug is unlikely to interact with other drugs metabolized by CYP450.
No changes in protein binding have been seen with coadministration of warfarin, diazepam, diclofenac sodium, ticlopidine hydrochloride, nifedipine, and nicardipine hydrochloride.
Since itopride has gastrokinetic effects it could influence the absorption of concomitantly orally administered drugs. Particular caution should be taken with drugs with a narrow therapeutic index, sustained release or enteric-coated formulations.
Anti-ulcer drugs like cimetidine, ranitidine, teprenone and cetraxate do not affect the prokinetic action of itopride.
Anticholinergic drugs may reduce the action of itopride.
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