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Each mL contains Irinotecan HCl trihydrate 20.0 mg, sorbitol 45.0 mg, lactic acid 0.9 mg and water for injection q.s.
Irinotel (irinotecan) is a semisynthetic derivative of the plant alkaloid camptothecin extracted from the Chinese tree Camptotheca accuminata. Irinotecan is a promising antitumor agent with activity in a broad range of experimental tumor models. It inhibits topoisomerase I function by binding to the topoisomerase I/DNA-cleavable complex.
Irinotecan hydrochloride trihydrate is a pale yellow to yellow crystalline powder with high antitumor activity. Chemically it is (4S)-4, 11-diethyI-4-hydroxy-9-[(4-piperi-dinopiperidino) carbonyloxy]-1 H-pyrano [3', 4':6, 7] indolizino [1,2-b] quinoline-3,14(4H,12H) dione hydrochloride. It is slightly soluble in water and organic solvents. It has an empirical formula of
C33H38N4O6.HCI.3H2O and a molecular weight of 677.19.
