Ingliptin Dosage/Direction for Use

Recommended Dose: Adult: Usual dosage: 1 tablet once daily.
Concomitant therapy: When Sitagliptin phosphate is used in combination with an insulin secretagogue (eg. sulfonylurea) or with insulin, a Sitagliptin dosage of 100 mg once daily has been used. A lower dose of insulin secretagogue or insulin may be required to reduce the risk of hypoglycemia. When Sitagliptin phosphate is used in combination with a thiazolidinedione antidiabetic agent (eg. pioglitazone, rosiglitazone) with or without metformin, a Sitagliptin dosage of 100 mg once daily has been used.
Renal impairment: Dosage adjustment is recommended for patients with moderate or severe renal impairment or end-stage renal disease requiring hemodialysis or peritoneal dialysis.
Patients with moderate renal impairment (creatinine clearance of 30 to less than 50 ml/minute), the recommended dosage of Sitagliptin is 50 mg once daily.
Patients with severe renal impairment (creatinine clearance less than 30 ml/minute), the recommended dosage of Sitagliptin is 25 mg once daily.
Patients with end-stage renal disease requiring hemodialysis or peritoneal dialysis should receive a dosage of 25 mg once daily. Sitagliptin phosphate may be administered without regard to the timing of dialysis.
Mode of Administration: Sitagliptin phosphate should be administered orally once daily with or without food.