Imcitin Dosage/Direction for Use

IMCITIN is available in intravenous infusion.
The dosage recommendations for IMCITIN represent the quantity of imipenem to be administered. An equivalent amount of cilastatin is also present.
The total daily dosage and route of administration of IMCITIN should be based on the type or severity of infection and given in equally divided doses based on consideration of degree of susceptibility of the pathogen(s), renal function and body weight. (See Tables 1, 2 and 3.)

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Patients with creatinine clearance of ≤5 mL/min/1.73 m² should not receive IMCITIN unless hemodialysis is instituted within 48 hours.
Patients weighing <30 kg with impaired renal function should not receive IMCITIN.
Hemodialysis: Use the dosing recommendation for patients with a Cl_Cr 6-20 mL/min/1.73 m².
Peritoenal dialysis: Dose as for Cl_Cr <10 mL/min/1.73 m².
Administration: Not for direct infusion; vial contents must be transferred to 100 ml of infusion solution; final concentration should not exceed 5 mg/ml; Each dose of 250-500 mg of IMCITIN should be given by intravenous infusion over 20 to 30 minutes. Each dose 1 g of IMCITIN should be infused over 40 to 60 minutes; watch for convulsion. In patients who develop nausea during the infusion, the rate of infusion may be slowed.