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Posology: In general, the dosage and the infusion-rate should be adjusted to the patient's individual requirements.
When human albumin is used in replacement therapy, the dosage required is guided by the usual circulatory parameters.
The lowest limit for the colloidal osmotic pressure is 20 mmHg (2.7 kPa). If human albumin is to be administered, the dose in grams required can be estimated using the following calculation: [required total protein (g/l) - actual total protein (g/l)] x plasma volume (l) x 2.
The physiological plasma volume may be calculated as approximately 0.04 l/kg body weight.
As the formula in any case is only approximate, laboratory monitoring of achieved protein concentration is recommended.
In cases of extensive substitution and in cases with haematocrit below 30% see "Precautions".
Paediatric use: In children the physiological plasma volume is age-dependent, this fact must be taken into account.
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