HOFXIB 90 is contraindicated in patient with known hypersensitivity to any component of this product; patients with congestive heart failure (NYHA class II-IV); patient with active peptic ulceration or gastro-intestinal (GI) bleeding; patient with severe hepatic dysfunction (Child-Pugh score >9); patient with severe renal impairment (CrCl <30 mL/minute); patient who have history of allergy-type reaction; asthma, acute rhinitis, nasal polyps, angioedema, urticaria following the administration of aspirin or other NSAIDs (Non-steroidal anti-inflammatory drugs); pregnancy and breastfeeding; children <16 years; patient with inflammatory bowel disease; patient with uncontrolled hypertension (persistently above 140/90 mmHg); patient with ischemic heart disease, peripheral artery disease and/or cerebrovascular disease (including patient who have recently undergone coronary artery bypass graft (CABG) surgery or angioplasty.
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