Glycon MR Drug Interactions

Alcohol (Ethanol): Major potential reactions associated with ethanol use and sulfonylurea include prolonged hypoglycemia and disulfiram-like reactions.
Aminolevulinic Acid: Concurrent use of Gliclazide and aminolevulinic acid may increase the risk of phototoxic skin reaction.
Avoid concomitant use.
Antibacterials: Chloramphenicol markedly inhibits the metabolism of sulfonylureas which can result in hypoglycaemia. Sulfonamides may also enhance the hypoglycaemic effects of the sulfonylureas. There have been rare reports of hypoglycemia when fluoroquinolones (i.e. ciprofloxacin, levofloxacin, gatifloxacin) were used with sulfonylurea.
Antifungals: Concurrent use of Gliclazide and azole antifungals (i.e. fluconazole, miconazole, ketoconazole, voriconazole) may increase the effects of Gliclazide. Hypoglycemia has been reported.
Cimetidine: Concurrent use of Gliclazide and cimetidine may increase the effects of Gliclazide. Increased hypoglycemic effect may occur.
Rifampin: Concurrent use of Gliclazide and rifampin has been shown to reduce the glucose-lowering effects of Gliclazide. Increased dose of Gliclazide may be necessary.